Sn™222 Deep™

In order to fall asleep, the body and brain need to relax. Magnesium is involved in the regulation of melatonin and GABA, and may aid sleep by activating the parasympathetic nervous system if you feel stressed.  Studies show that elderly people may experience improved sleeping from magnesium supplements.

L-theanine, also known as γ-glutamylethylamide, is an amino acid that structurally very similar to the amino acid l-glutamate. L-glutamate, also known as simply glutamate, acts a neurotransmitter in the brain. In accordance, l-theanine has been shown to bind to glutamate receptors (although with much lower afinity than glutamate itself), resulting in the increase of serotonin and dopamine levels in various parts of the brain.

In one study with 30 healthy adults, L-theanine has shown improved sleeping with less time to fall asleep, fewer sleep disturbances and less sleep medication needed than the control group. In another study, healthy participants were given 50 mg L-theanine or a placebo, and brain waves were measured continously. Alpha-wave production was significantly higher in the L-theanine group compared to the placebo group. Alpha wave activity increase is a marker for awake relaxation - the same effect as you get during meditation.
https://pubmed.ncbi.nlm.nih.gov/18296328/

In adition, a study of Japanese university students found that 200 mg of L-theanine led to increased brain alpha-waves and a subjective sense of relaxation, along with decreased stress-related beta-waves. In the same study, L-theanine administration also caused a dose-dependent relaxed, yet alert, state of mind without sedation, beginning approximately 40 minutes after ingestion.* In this study, L-theanine was compared with water and GABA (as PharmaGABA®). Both L-theanine and PharmaGABA significantly increased alpha-wave production.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/

While certain sleeping pills can be highly effective in assisting sleep when experiencing suboptimal sleep, there are three main reasons why we do not promote their use:

1. Dependency and Tolerance: Regular use of prescription sleeping pills can lead to dependency and tolerance. The body can become accustomed to the medication, requiring higher doses to achieve the same effect. This often results in increased difficulties in falling asleep without the medication. Additionally, most sleeping pills are not recommended for long-term use.
   
   

2. Side Effects: Prescription sleeping pills can cause various side effects, including daytime drowsiness, headaches, memory problems, and impaired coordination.
   
   

3. Withdrawal Symptoms: Discontinuing the use of prescription sleeping pills after prolonged use can result in withdrawal symptoms, such as anxiety, irritability, and rebound insomnia.

Yes, Sn™222 Deep™ is suitable for daily use if you follow the provided instructions.

Many of our users use Sn™222 Deep™ daily and experience long-term benefits, both in terms of sleep quality and overall well-being.

Sn™222 Deep™ helps you relax, making it easier to fall asleep quickly. If you wake up in the middle of the night, the tablets still affect your body, allowing you to fall back asleep faster. The positive effects increase over time. Some individuals may notice a real difference after 4-5 nights.

If you experience prolonged sleep problems, we recommend seeking professional help to identify and treat the underlying causes of your sleeping difficulties.

Apigenin

Salehi B, Venditti A, Sharifi-Rad M, Kręgiel D, Sharifi-Rad J, Durazzo A, Lucarini M, Santini A, Souto EB, Novellino E, Antolak H, Azzini E, Setzer WN, Martins N. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019 Mar 15;20(6):1305. doi: 10.3390/ijms20061305. PMID: 30875872; PMCID: PMC6472148. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/

Yurcheshen M, Seehuus M, Pigeon W. Updates on Nutraceutical Sleep Therapeutics and Investigational Research. Evid Based Complement Alternat Med. 2015;2015:105256. doi: 10.1155/2015/105256. Epub 2015 Jul 21. PMID: 26265921; PMCID: PMC4523676.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523676/

Andressa C. Gazola, Geison M. Costa, Leonardo Castellanos, Freddy A. Ramos, Flávio H. Reginatto, Thereza C.M. de Lima, Eloir P. Schenkel,
Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp,
Revista Brasileira de Farmacognosia,
Volume 25, Issue 2, 2015, Pages 158-163, ISSN 0102-695X.
https://www.sciencedirect.com/science/article/pii/
S0102695X15000678

Zick, S.M., Wright, B.D., Sen, A. et al. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study. BMC Complement Altern Med 11, 78 (2011). https://doi.org/10.1186/1472-6882-11-78
https://bmccomplementmedtherapies.biomedcentral.com
/articles/10.1186/1472-6882-11-78

L-Theanine

Theertham P. Rao , Motoko Ozeki & Lekh R. Juneja (2015) In Search of a Safe Natural Sleep Aid, Journal of the American College of Nutrition, 34:5, 436-447, DOI: 10.1080/07315724.2014.926153
https://www.tandfonline.com/doi/abs/10.1080/
07315724.2014.926153?journalCode=uacn20

Duygu Türközü & Nevin Şanlier (2017) L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety, Critical Reviews in Food Science and Nutrition, 57:8, 1681-1687, DOI: 10.1080/10408398.2015.1016141
https://www.tandfonline.com/doi/abs/10.1080/
10408398.2015.1016141?journalCode=bfsn20

Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
https://pubmed.ncbi.nlm.nih.gov/31623400/

Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011 Dec;16(4):348-54. PMID: 22214254.
https://pubmed.ncbi.nlm.nih.gov/22214254/ 

Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L, Lerner V. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry. 2011 Jan;72(1):34-42. doi: 10.4088/JCP.09m05324gre. Epub 2010 Nov 30. PMID: 21208586.
https://pubmed.ncbi.nlm.nih.gov/21208586/

Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012 Oct 29;31(1):28. doi: 10.1186/1880-6805-31-28. PMID: 23107346; PMCID: PMC3518171.
https://pubmed.ncbi.nlm.nih.gov/23107346/

Stough, C., & Pase, M. P. (2015). Improving Cognition in the Elderly With Nutritional Supplements. Current Directions in Psychological Science, 24(3), 177-183. https://doi.org/10.1177/0963721414565449
https://journals.sagepub.com/doi/abs/
10.1177/0963721414565449

Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. doi: 10.1016/j.biopsycho.2006.06.006. Epub 2006 Aug 22. PMID: 16930802.
https://pubmed.ncbi.nlm.nih.gov/16930802/

Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. Epub 2014 Dec 23. PMID: 25533534; PMCID: PMC4397399.
https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC4397399/

Magnesium

Arab A, Rafie N, Amani R, Shirani F. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature. Biol Trace Elem Res. 2023 Jan;201(1):121-128. doi: 10.1007/s12011-022-03162-1. Epub 2022 Feb 19. PMID: 35184264.
https://pubmed.ncbi.nlm.nih.gov/35184264/

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec;17(12):1161-9. PMID: 23853635; PMCID: PMC3703169.
https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC3703169/

Mah, J., Pitre, T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis. BMC Complement Med Ther 21, 125 (2021). https://doi.org/10.1186/s12906-021-03297-z.
https://bmccomplementmedtherapies.biomedcentral
.com/articles/10.1186/s12906-021-03297-z 

Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr. 1994 Sep-Oct;18(5):430-5. doi: 10.1177/0148607194018005430. PMID: 7815675.
https://pubmed.ncbi.nlm.nih.gov/7815675/